Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
نویسندگان
چکیده مقاله:
A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed antimycobacterial activity with IC90, 7.57 and 2.96 µg/mL, respectively.
منابع مشابه
synthesis and antimycobacterial activity of 2-(phenylthio) benzoylarylhydrazone derivatives
a series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. the chemical structures of the compounds were elucidated by ft-ir, 1h-nmr and mass spectra. all newly synthesized compounds were evaluated for their antimycobacterial activities against mycobacterium tuberculosis h37rv using the microplate alamar blu...
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عنوان ژورنال
دوره Volume 10 شماره 4
صفحات 727- 731
تاریخ انتشار 2011-09-13
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